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Detection of High Expression Levels of EMT-Transcription Factor mRNAs in Patients With Pancreatic Cancer and Their Diagnostic Potential - EMT PC 1.1

Studio Clinico

Patologia: Carcinoma del pancreas esocrino

Osservazionale-Sperimentale: Osservazionale

Monocentrico-Multicentrico: Multicentrico

Randomizzato: No

Fase di studio: Non applicabile

Linee di trattamento: Non applicabile

Criteri di inclusione: 

- Males or females over 18 years of age capable of providing informed consent.
- Pancreatic carcinoma confirmed by tissue biopsy or colon mass, clinically consistent with cancer and eventually confirmed by pathology.
- Subject were enrolled following colon cancer screening via colonoscopy

Criteri di esclusione: 

- Patients under the age of 18 years or over the age of 80 years.
- Patients with personal history of cancer, identification of large polyp or adenomatous pathology on previous or subsequent colonoscopy
- Patient with history of abdominal surgery within the past four months
- Patients unwilling to or unable to give informed consent.
- Patients with acute inflammatory diseases or under any emergency condition.
- Pregnant women.

Schema di trattamento: 


Trattamento sperimentale: 

Diagnostic Test: Liquid biopsy
Detection and quantification of EMT-transcription factor mRNA levels in blood

Trattamento di controllo: 


Obiettivi primari dello studio: 

The present study is aimed at detecting and measuring mRNA levels of genes involved in epithelial to mesenchymal transition (EMT) in biological samples, i.e. in peripheral blood samples of pancreatic cancer (PC) patients and healthy controls, to determine the presence of disease, its progression and risk of recurrence.

Centri partecipanti

Nord Italia

Ospedale San Raffaele di Milano
Via Olgettina 60 - 20132 Milano - MI


Istituto Clinico Humanitas Rozzano
Via Manzoni 56 - 20089 Rozzano - MI

Riferimento: Prof. Luigi Laghi
Telefono: 0282244572

Informazioni Generali


Numero di iscrizione a registro: NCT04323917

Data di inserimento: 03.08.2020


Isituto Clinico Humanitas, Rozzano (Mi)



Principal Investigator ITALIA

Isituto Clinico Humanitas, Rozzano (Mi)

Riferimento: Prof. Luigi Laghi

Telefono: 0282244572


Localita: Rozzano (Mi)


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