S095032-211 - A Phase 1b/2, Multicenter Study of Vorasidenib in Combination With Temozolomide (TMZ) in Participants With IDH1- or IDH2-mutant Glioma

Studio Clinico

Patologia: Neoplasie cerebrali

Osservazionale-Sperimentale: Sperimentale

Monocentrico-Multicentrico: Multicentrico

Randomizzato: No

Fase di studio: 1, I B, II

Linee di trattamento: Prima linea

Criteri di inclusione: 

- Be ≥12 years of age with a weight at screening ≥40 kg.
- Have documented IDH1 or IDH2 mutation based on local testing of tumor tissue by an accredited laboratory
- Have adequate renal function, defined as a creatinine clearance ≥40 mL/min based on the Cockcroft-Gault glomerular filtration rate estimation: (140 - Age) × (Weight in kg) × (0.85 if female) / 72 × serum creatinine (mg/dL).
- Have adequate bone marrow function as evidenced by:
    - Absolute neutrophil count ≥1,500/mm3 or 1.5×109/L
    - Hemoglobin ≥9 g/dL or 90 g/L
    - Platelets ≥100,000/mm3 or 100×109/L
- Have expected survival of ≥3 months.
KPS or LPPS ≥70 at the start of study treatment.
- Participants on corticosteroids for reasons related to glioma must be on a stable or decreasing dose (≤4mg/day dexamethasone or equivalent) for ≥5 days before the start of study treatment.
- Female participants of reproductive potential must have a negative serum pregnancy test before starting study treatment.

Phase 1b ONLY:

- Have histologically confirmed Grade 2, 3 or 4 IDHm (as per WHO 2021) glioma (astrocytoma or oligodendroglioma).
    - For oligodendroglioma: Have local testing at an accredited laboratory demonstrating presence of 1p19q co deletion
    - For astrocytoma: Have local testing by an accredited laboratory demonstrating lack of 1p19q co-deletion and/or documented loss of nuclear ATRX expression or ATRX mutation
- Are appropriate to receive TMZ as post-radiotherapy (RT) adjuvant therapy or as treatment for first disease recurrence after prior RT and/or chemotherapy, per Investigator judgement. For those receiving TMZ in the post-RT adjuvant setting, study treatment must begin no more than 6 weeks after completion of RT.
- Have adequate hepatic function as evidenced by:
    - Serum total bilirubin ≤1.5×upper limit of normal (ULN); if ≥1.5×ULN and due to Gilbert syndrome, total bilirubin ≤3×ULN with direct bilirubin ≤ULN,
    - AST and ALT ≤ULN, and
    - Alkaline phosphatase ≤2.5×ULN.

Phase 2 ONLY:

- Have histologically confirmed Grade 4 astrocytoma, IDHm (per 2021 WHO criteria). Those who meet the Grade 4 designation via homozygous deletion of CDKN2A/B are eligible.
- Have absence of 1p19q co-deletion (i.e., non-co-deleted, or intact) and/or documented loss of nuclear ATRX expression or ATRX mutation by local testing.
- Have received SOC RT with concurrent TMZ (RT-TMZ) before enrollment. Study treatment must begin no more than 6 weeks after completion of RT-TMZ.
- Have adequate hepatic function as evidenced by:
    - Serum total bilirubin ≤1.5×ULN; if ≥1.5×ULN and due to Gilbert syndrome, total bilirubin ≤3×ULN with direct bilirubin ≤ULN,
    - AST and ALT at or below the upper limit of normal. An elevation ≤1.5×ULN and considered not clinically significant by the Investigator may be allowed after Medical Monitor (Sponsor) approval, and
    - Alkaline phosphatase ≤2.5×ULN.

Criteri di esclusione: 

- Unable to swallow oral medication.
- Are pregnant or breastfeeding.
- Are participating in another interventional study at the same time; participation in non-interventional registries or epidemiological studies is allowed.
- Have leptomeningeal disease.
- Have a known coagulopathy.
- Received prior therapy with an IDH inhibitor, IDH-directed vaccine, or bevacizumab.
- Have a history of another concurrent primary cancer, with the exception of:
    - curatively resected non-melanoma skin cancer, or
    - curatively treated carcinoma in situ.
Participants with other previously treated malignancies are eligible provided they have been disease-free for 3 years at Screening.
- Have a known diagnosis of replication repair-deficient glioma (e.g., a known diagnosis of constitutional mismatch repair deficiency or Lynch syndrome).
- Have a known hypersensitivity to any of the components or metabolites of vorasidenib or TMZ.
- Have significant active cardiac disease within 6 months before Screening, including New York Heart Association (NYHA) Class III or IV congestive heart failure, myocardial infarction, unstable angina, and/or stroke.
- Have heart rate corrected QT interval (using Fridericia's formula) (QTcF) ≥450 msec or have other factors that increase risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome). Right bundle branch block and prolonged QTcF interval may be permitted based on local cardiology assessment.
- Have known active hepatitis B (HBV) or hepatitis C (HCV) infections, known positive human immunodeficiency virus (HIV) antibody results, or acquired immunodeficiency syndrome (AIDS) related illness. Participants with a sustained viral response to HCV treatment or immunity to prior HBV infection will be permitted. Participants with chronic HBV or HIV that is adequately suppressed per institutional practice will be permitted.

Trattamento sperimentale: 

Phase 1b: Vorasidenib and Temozolomide (TMZ)
Phase 2: Vorasidenib recommended combination dose (RCD) and Temozolomide (TMZ)

Trattamento di controllo: 

NA

Centri partecipanti

Nord Italia

Informazioni Generali

Protocollo

Numero di iscrizione a registro: 2024-513738-39-00

Data di inserimento: 03.06.2025

Promotore

Institut de Recherches Internationales Servier

Principal Investigator ITALIA

Riferimento: Dr. Info non applicabile

Telefono: 00000

Email: na@na.it

Localita: na